Azelastine is unique among antihistamines presently available in the USA because it is administered by nasal spray. After intranasal administration, its systemic bioavailability is approximately 40%. Azelastine has an onset of action within the first hour of administration and reaches peak activity at 1–3 hours after administration. Duration of activity is about 12 hours. Intranasal administration results in maximal plasma concentrations in 2–3 hours. Azelastine has an active metabolite, desmethylAzelastine, which probably extends the duration of action of the drug. The half-life of the parent compound is 22 hours and that of the active metabolite 54 hours. Ten days after oral administration of 4 mg radiolabeled Azelastine, approximately 24% of the radioactivity was recovered in the urine and 75% in the feces.
Other names for this medication:
Azelastine,
Afluon,
Allergodil,
Astelin,
Astepro,
Asthafen,
Azel,
Azelastin,
Azelastina,
Azelone,
Azen,
Azep,
Azeptin,
Ketasma,
Lastin,
Optilast,
Optivar,
Otrivine,
Phenergan,
Rhinolast,
Rinalin,
Xanaes,
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There is great debate about the costs augmentin dose for pediatric uti and benefits of technology-driven medical interventions such as instrumented lumbar fusion. Recently, interest in intrinsic resistance genes has increased, because these gene products not only may provide attractive therapeutic targets for development of novel drugs that rejuvenate the activity of existing antibiotics, and but also might predict future emergence of resistant pathogens if they become mobilized.