Elazor is a synthetic compound known as a bis-triazole. It was first used in patients 1994/95 and licensed for use in 1990. It went off patent in 2003. It works by inhibiting the production of ergosterol, a central chemical in the cell walls of fungi. The drug is available as a capsule, oral suspension and intravenous infusion. A typical dose for oral thrush is 100mg per day. The typical dose for vaginal thrush is a 150mg per day. For the prevention of fungal infections in leukaemia, doses from 50-400mg per day have been used and studied. Most authorities recommend between 100 and 400mg. For the treatment of candidemia and other serious Candida infections a minimum dose of 400mg per day (after a loading dose of 800mg) is recommended with increased doses in patients on haemofiltration and/or rifampicin (see below). Some authors have suggested that 800mg is superior for candidaemia, but the data is not compelling. For the treatment of cryptococcal meningitis after amphotericin B, a minimum of 400mg per day initially is used until the patient is stable and then typically 200mg per day. Much larger doses e.g. 800-1200mg per day should be used as an alternative primary regimen (preferably with flucytosine) or for patients failing therapy. Larger doses such as 800-1200mg per day have been used for coccidioidal meningitis. Almost all other treatments have been for 100-400mg per day. Reduced doses may be appropriate in severe renal dysfunction.
Other names for this medication:
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