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Endoxana (Cyclophosphamide)

Endoxana is a cytotoxic (cytostatic), cell-cycle-nonspecific, antiproliferative agent that is used in such diverse medical problems as neoplasia, tissue transplantation, and inflammatory diseases. It is an inert prodrug for a potent nitrogen mustard alkylating agent. After the metabolic activation of Endoxana to the potent mustard by liver enzymes, a nonenzymatic generation of chemically reactive molecules occurs. These reactive molecules can form covalent bonds with biologically ubiquitous groups, such as amino, phosphate, hydroxyl, carboxyl, sulfhydryl and imidazole, and as a result, depending on dose, Endoxana is capable of either interfering with the reproduction of cells or killing cells. This is especially true in the case of rapidly dividing cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Type I glycogen storage disease (GSD) is a rare autosomal recessive disorder caused by glucose-6-phosphatase deficiency. Immunohistochemistry and microscope spectrophotometry showed that AGE deposition increased significantly in the aorta and vessels of the myocardium, depending on the period of hyperglycaemia. Treatment of aortic-banded animals with the angiotensin-converting enzyme inhibitor quinapril and the antioxidant vitamin C, either alone or in combination, did not affect BP but caused a significant inhibition of the increases in the heart-to-body weight ratio, ANG II, ET-1, and TNF-alpha levels, and O production and restored cGMP responses to levels comparable with sham-operated animals. Uncovering a rare but critical complication following thyroid surgery: an audit across the UK and Ireland. To determine the impact of potential artifacts on pH monitoring of the hypopharynx and esophagus.

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Comparison of the structure of turtle pancreatic ribonuclease with those of mammalian ribonucleases. Each of these promoters directed high-level GFP expression in mouse photoreceptors. Tasks were performed with left and right hands and cued auditorily at variable intervals. To determine the efficacy of rAAV.sFlt-1-mediated gene therapy in a transgenic mouse model of retinal neovascularization (trVEGF029) and to assess whether rAAV.sFlt-1 administration generated any deleterious, long-lasting immune response that could affect efficacy. Unrelated donor hematopoietic cell transplantation for non-hodgkin lymphoma: long-term outcomes.

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The aim of this study was to determine the rate and significance of TERT promoter mutations that have been recently described in adult thyroid cancer (TC) but not yet in the uncommonly occurring pediatric TC. The presence of PSVC may complicate implantation, but it does not influence the long-term follow-up of pacing parameters.

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We present a retrospective study regarding our experience with ultrasonography in the diagnosis of urologic problems. Development of an interactive motivating tool for rehabilitation movements. This paper presents a means to eliminate all differential operations by using the integration-by-parts method to provide closed-form formulas, so that the mathematical model is less sensitive to data sampling and noise.

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Angelman syndrome (AS) is a complex neurological disorder with different genetic aetiologies. Properties of rapidly labelled deoxyribonucleic acid fragments isolated from the cytoplasm of primary cultures of embryonic mouse liver cells. Supermicrosurgical lymphatico comitantes perforator venule anastomosis for the treatment of peripheral lymphedema: A new configuration for patients with superficial vein insufficiency?

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