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Escitalopram is the S-isomer of the racemic compound citalopram, a selective serotonin reuptake inhibitor (SSRI) that is widely used in both psychiatric and primary care practices for the treatment of depression. The theoretical rationale for separating a single isomer from its parent compound and synthesizing it into a new therapeutic agent is 2-fold. First, it may capture the molecule that is actually responsible for the desired therapeutic action. At the same time, it may isolate and remove the molecule that is not only therapeutically unproductive but may be the source of undesirable pharmacologic activity. The result is a “purer” agent, one that can potentially offer an improved safety and efficacy profile versus the parent compound.

Other names for this medication:
Escitalopram, Lexapro, Aramix, Celtium, Cipralex, Citoles, Ectiban, Entact, Esertia, Esipram, Esita, Eslorex, Esram, Gaudium, Lexamil, Lextor, Losiram, Losita, Neozentius, Nexcital, Seroplex, Sipralexa, Tiopram,

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Five surface receptors were studied, and the expression differed significantly in all five between AM and IM. Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides.

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Included were all trials published in English that assessed cognition before and after an exercise intervention in human adults with TBI or stroke. A low level of mRNA coding for the 70 KDa SP--the most prominent among the inducible SPs-was constantly found in all specimens. The results of the study will help to convince policy makers and those involved in training healthcare workers in Brazil of the public health advantages of the syndromic approach, as an essential part of STD/HIV control activities. Forward genetics approaches have helped elucidate the anthocyanin biosynthetic pathway in plants.

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The automated cultivation and dissemination of a variety of suspension cells can replace the manual method. Intensive care units, scarce resources, and conflicting principles of justice.

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Lung function tests with simple and advanced oscilloresistometry. The results of Western blotting test indicated that there was no change of C99 contents and beta-secretase activity in gamma-schisandrin treated cells, while gamma-secretase activity decreased obviously. This requires information about the thermal neutron dose component around the Cf source. Romiplostim in children with chronic immune thrombocytopenia (ITP): the French experience.

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Presence of pluripotent haemopoietic precursors in vitro (CFU-mix) in haemopoietic tissues from mice of W/Wv genotype. A positive correlation was demonstrated between a medical school academic record and the interview, especially for unblinded interview formats. In this study we analyzed three cases of patients affected by L.C.D.: two of them suffered from insulin-dependent diabetes mellitus (IDDM) and the other one from infantile cerebral palsy and eosinophilic gastroenteritis.

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As an application of our method, we use the structure-from-motion output to stabilise the viewing direction in fully spherical video. We studied 131 men, aged 56-77 years, with treated hypertension and at least one additional cardiovascular risk factor (hypercholesterolaemia, diabetes mellitus or smoking). Biophysical parity of a donor with a recipient that represents their metabolic parity is suggested as a criterion of histocompatibility Activation cross section and isomeric cross-section ratio for the 93Nb(n, alpha )90Ym,g process.

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We have characterized and quantified the proteome of the Nostoc sp. The Taiwan Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Cancer 30 (EORTC QLQ-C30) and the supplementary gastric cancer module QLQ-STO22 were used as outcome measures. Both global and nodal properties of functional networks in three sub-stages were statistically analyzed.

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Fifteen Shetland ponies were used in a 7-wk trial to study the effect of supplemental Se on humoral antibody production. This suggests that the generation and propagation of motion signals at cyclopean levels of vision play a part in the representation of coherently-moving rigid surfaces.

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Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci. Evidence of interventions for the risk of dry eye in critically ill patients: An integrative review.

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Our data suggest that MI screening is probably not an efficient strategy for identifying HNPCC cases. As a result of continuing progress in the development of intervention materials but also due to growing understanding of pathophysiological relationships, the prevalence and significance of endovascular interventions in the head and neck region have continued to increase. Feeding trials were conducted with broiler breeder hens to determine optimum daily intake of protein for maximum performance.

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The bacterium is slow-growing and nutritionally fastidious, such that other indigenous species can out-compete the Legionella even when using antibiotic supplemented media. Raft-targeted PLCgamma1 was constitutively tyrosine phosphorylated and induced constitutive NF-AT-dependent transcription and interleukin-2 secretion in Jurkat cells. The addition of bevacizumab to the standard R-CHOP regimen did not appear to significantly improve efficacy beyond that observed from previous studies using R-CHOP alone.

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Challenges for Diagnosis of Malaria and Neglected Tropical Diseases in Elimination Settings. The most frequent causes of Eosinophilic meningitis are parasitic and fungal infections.

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A generalized decrease in the mobility of pharyngeal structures is demonstrated after radiotherapy. However, the effect of antibiotic treatment of cases with PE and chronic prostatitis has not been extensively investigated. Percutaneous stenting to treat pulmonary vein stenosis after single-lung transplantation. Patient Stage of Change predicts outcome in a panic disorder medication trial.

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This study aimed to identify detailed differences in laparoscopic surgical processes between expert and novice surgeons in a training environment and demonstrate that surgical process modeling can be used for such detailed analysis. If anybody showed positivity, they were tested by two ELISA kits (screening and confirmatory) and then confirmed infection status by NAT and or RIBA.

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Clinical correlations of chronic hepatitis C, diabetes mellitus and steatohepatitis These CTP reflect typical treatment approaches and are not to be considered treatment recommendations or standard of care. This model underscores the central role of P at the interface between L protein and N-RNA template.

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Draft Genome Sequence of Paenibacillus polymyxa Strain Mc5Re-14, an Antagonistic Root Endophyte of Matricaria chamomilla. Infections with American hantaviruses may lead to hantavirus pulmonary syndrome characterised by severe cardiopulmonary distress with high mortality. These procedures are usually classified as contaminated, with a 20 to 30 percent infection rate, or dirty, with a more than 30 percent infection rate, depending upon several factors. In conclusion, our studies demonstrate that barrier disruption due to acetone treatment is mainly due to removal of corneocytes.

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These results demonstrate that PgLOX6 is responsible for the biosynthesis of JA and promotion of the production of triterpenoid saponin through up-regulating the expression of ginsenoside biosynthetic genes. In this study, we show that deleting mGluR5 expression only in principal cortical neurons leads to defective cannabinoid receptor 1 (CB1R) dependent synaptic plasticity in the prefrontal cortex. For each patient, a 10-mL blood sample was obtained from a 20-gauge or larger peripheral venous catheter after a 3-mL volume of fluid was discarded.

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However, LIF and OSM, which are potent inducers of STAT 3, are less potent activators of STAT 1 as measured by both tyrosine phosphorylation and nuclear translocation. This information could be used to guide training decisions and to support doctors during their training period. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.

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Carbon clusters on the Ni(111) surface: a density functional theory study. To estimate misclassification of ethnicity and cancer incidence in Southeast Asian children using the population-based California Cancer Registry. Lasers and light sources have been used to treat pigmented lesions, but in Asian skin with higher melanin content, such treatments may be challenging. Here, we present all the information necessary to execute the lesson effectively with middle and high school students. Increasing length of stay to optimize IV thiamine replacement will place additional strain on acute care but has potential UK public sector cost savings.

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Analyses of internal carotid artery stenosis defined by multiple different cutoffs of peak systolic velocity, rather than one particular cutoff, were performed in the 5441 participants who underwent carotid ultrasound and lacked a history of transient ischemic attack or stroke. It has been reported that Qiliqiangxin (QL), a traditional Chinese medicine compound, could inhibit cardiac hypertrophy and remodeling, and improve cardiac function. Predicting rectal carcinoid behavior based exclusively on tumor size is imprecise. From this phylogeny we infer ancestral states of the ion selectivity filter and show that this state has been retained in the choanoflagellate and placozoan channels. However, derived parameters are sensitive to the presence of partially opened zones along the crack whose pattern may differ from one sample to another.

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Typical cross-section differences between theory and experiment range from about 25 percent to a factor of two. Statistical study of patients taking cures at spas in the Paris area There was an increase in problems and in consumption during the 1970s but a decrease in the 1980s, with the exception of the youngest cohort (1937-1945) who reported more problems in the 1991 assessment despite lower consumption. Tumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours.

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The same location of Rf-3 was also found in a BC(1) population from the cross of IR58025 A//IR36/IR58025 B. The latter is also the case for the BMP receptor BMPR1B to which GDF5 binds. When the uveitis was associated with lung, lymph node, skin, bone, or testicular lesions, the likelihood of blastomycosis was greater.

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Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. Thus vaccination with these exoantigens might provide a means of protection against the clinical effects of malaria and of generating anti-disease immunity by reducing cytokine production.

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Rest myocardial perfusion imaging (RMPI) during or immediately after an episode of chest pain can provide diagnostic and prognostic information concerning acute coronary syndromes. Targeting the PI3K/PTEN/AKT/mTOR Pathway in Treatment of Sarcoma Cell Lines. There is considerable controversy as to whether temporary relief of biliary obstruction prior to major definitive surgery (pre-operative biliary drainage) is of any benefit to the patient.

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The enzyme is highly regulated, as indicated by rapid changes in its mRNA and protein during cell growth. General considerations on angiography in diverse forms of stroke Thus, only the thymus autoantibodies induced by anti-Id treatment expressed Id-determinants.

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To provide guidance in choosing the most suitable vaccine formulation and timing of administration, it is necessary to understand the timing of influenza seasonal epidemics. Molecular aspects of the relationship of transmissible gastroenteritis virus (TGEV) with porcine respiratory coronavirus (PRCV). A random effects meta-analysis of effectiveness data was conducted if 2 or more studies reported a specified outcome. To investigate the effects of umbilical artery catheters (UACs) on superior mesenteric artery (SMA) blood flow velocity (BFV) following enteral feedings in very low birth weight preterm infants.

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Adaptive-Partitioning Redistributed Charge and Dipole Schemes for QM/MM Dynamics Simulations: On-the-fly Relocation of Boundaries that Pass through Covalent Bonds. For simulation of the hypokinetic effect all subjects were kept under an average of 3000 steps per day. REMOVED: Inhibition of doxorubicin-induced clastogenic effect by Aegle marmelos (L.) correa in cultured V79 cells. The authors studied 33 patients with acute unilateral peripheral vestibulopathy, including 29 with classic vestibular neuritis and 4 with simultaneous ipsilateral hearing loss, 18 healthy subjects and 15 surgical unilateral vestibular deafferented patients. Current Hajj and Umrah meningococcal disease preventative measures do not necessarily prevent carriage and transmission, which may result in local and international outbreaks among susceptible populations.

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The primed hepatocytes then respond to growth factors, including hepatocyte growth factor, epidermal growth factor, and transforming growth factor-alpha. Protective effects of Angelica sinensis polysaccharide against hyperglycemia and liver injury in multiple low-dose streptozotocin-induced type 2 diabetic BALB/c mice. Whole-body insulin sensitivity (IS) depends on a hepatic pathway, involving parasympathetic activation and hepatic nitric oxide (NO) production. The effect of copper compounds on pigment formation in Bacillus subtilis and Bacillus megaterium

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Therefore, Sox21 controls hippocampal adult neurogenesis via transcriptional repression of the Hes5 gene. Dye coupling to the motoneuron somata was not observed, although a low level of transfer might have been obscured by autofluorescence.

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Conversion of androgens to estrogens not dependent on testicular tissue in a patient with syndrome of total insensitivity to androgens. N-acetylglucosamine-6-phosphate deacetylase (NagA) was identified in a protein mixture secreted by S. Significant cardiomyopathy secondary to West Nile virus infection.

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Common pathological findings included miliary focal necrosis and abscess formation. Statistical analyses were performed to correlate these outcomes to clinical presentations and treatment regimens. The subcellular location and functions of these proteins were analyzed. Allergic responses are strongly associated with Th2-type immune responses, and modulation of the skewed Th2 response toward a more balanced response is the major goal of allergen immunotherapy (IT) in allergic disorders.

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The physiological recognition of a ligand takes place most efficiently in the F-actin-rich lamellipodium and is F-actin dependent in stages of formation and triggering and myosin II dependent for signal amplification. We observed that the activities of all antioxidant enzymes studied were significantly increased with age and that FR attenuated the age-related increase.

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We hypothesised that targeting the inferior trunk of the plexus guided by a nerve stimulator would obtain a higher success rate of ulnar nerve blockade than the traditional double-injection technique. Although GBM represents a single histopathologic diagnosis under current World Health Organization criteria, data from multiplatform molecular profiling efforts, including The Cancer Genome Atlas, indicate that multiple subgroups with distinct markers and biology exist. Cytokine mRNA expression was examined by means of quantitative RT-PCR.

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Students rated the course favorably overall and found they had learned and applied new knowledge and skills. We have derived the large sample properties of the proposed estimators.

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Forty-seven participants played the mirror game with the same gender-matched expert players. Multibody coarse-grained potentials for native structure recognition and quality assessment of protein models. In contrast, rhEPO treatment significantly attenuated the upregulation of TGF-beta1 and alpha-SMA and the downregulation of E-cadherin. For each field, recommendations and strategies were developed for implementation of a seamless pipeline from biorepositories to highly specialized high-throughput laboratories including the sustainable management and integration of OMICS data.

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The methodological approaches included cross-sectional surveys, retrospective analysis, qualitative studies, and usability testing. Similar translational switches are expected to be applicable also for eukaryotes such as yeasts, nematodes, insects, mammalian cells, and plants.

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When treated in the later larval stage, RNAi with either the common sequence or an EcR A specific sequence caused more severe effects and most larvae died prior to adulthood. Leukocyte entry into the CNS of Leishmania chagasi naturally infected dogs. The use of piezoelectric surgery enables a precise crestal bony incision in severely deficient ridge widths and aids in faster wound healing. While the twitch and maximal tetanic tensions of the slower and fatigue-resistant MUs increased, tensions of the faster and more fatigable MUs declined.

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Among ventilated patients with candidemia, those receiving fluconazole as initial monotherapy were significantly more likely to survive than those treated with an echinocandin. Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs.

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Diclofenac sodium produced significant dose-related increases of threshold and tolerance to electrically and threshold to thermally induced pain. We show that depletion of reactants at larger distances causes development of larger pores in the coating, which affects its morphology, density and thickness. Improved ex vivo blood compatibility of central venous catheter with noble metal alloy coating.

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Effect of polyinosinic acid-polycytidylic acid on establishment, and on spontaneous and chemical transformation of Balb/c mouse-embryo cells in culture. Electric current also may not be effective for mature cells having no potential for proliferation. Live bird markets characterization and trading network analysis in Mali: Implications for the surveillance and control of avian influenza and Newcastle disease. To study the age and gender distribution of colorectal tumor type, location, and stage of colorectal tumors among urban minorities.

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Even if the technologist observes all the rules in performing the tests, there is still a potential source of error in the machine. Flat surfaces of artificially-carious enamel, softened in an intra-oral experiment, and naturally-carious (white spot) enamel were polished to a high gloss with diamond lapping compound, rendering them almost featureless by secondary electron scanning electron microscopy. Three-year follow-up of the fall risk and physical function characteristics of the elderly participating in a community exercise class. The presence of chronic total occlusions (CTO) increases the complexity of endovascular procedures and open surgery may often be the preferred approach. Computer-assisted osteodensitometry following total hip arthroplasty.

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Expression in thoracic aortic of inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NOS was then determined. Functional validation of a human CAPN5 exome variant by lentiviral transduction into mouse retina. Extra-abdominal desmoid tumor is a locally aggressive neoplasm that occurs most commonly in the pelvic or shoulder region in the third or fourth decade. As compared with RA, hyperoxic-PL pups had decrease in alveolarization and in lung vascular density, and this was associated with increased right ventricular systolic pressure (RVSP), right ventricular hypertrophy, and vascular remodeling.

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Among splenectomy patients, 13 had an excellent response, and 8 fulgram 500 mg uso had a fair or poor response. Electric conductivity and phase diagram of a mixed-stack charge-transfer crystal: Tetrathiafulvalene-p-chloranil. The phenolic recognition profiles of the Agrobacterium tumefaciens VirA protein are broadened by a high level of the sugar binding protein ChvE. Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Residual hematic pigmentation lesions were also eliminated with the laser.

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None of the 5 normal thymocyte samples constitutively expressed RNA for TGF-beta1 or GM-CSF. Both drug-eluting stents were associated with a marked reduction in target-lesion revascularization. SHREC consists of a core quartet of proteins - Clr1, Clr2, Clr3, and Mit1 - which distribute throughout all major heterochromatin domains to effect TGS via distinct activities associated with the histone deacetylase Clr3 and the SNF2 chromatin-remodeling factor homolog Mit1. DNA methylation and the social gradient of osteoporotic fracture: A conceptual model. According to the flow cytometry assay result, the herbal amitriptyline for sleep 100mg extract was able to induce apoptosis in colorectal cancer cells.

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The peptidin tab hunter positive rate in subsequent repeat biopsy is higher than that for cases with usual nodular hyperplasia. Participants were patients with AD, irritant hand dermatitis, and/or ichthyosis vulgaris. Here we report that CNS delivery of IFN-gamma before EAE onset ameliorated the disease course and prevented demyelination, axonal damage, and oligodendrocyte loss. With and without the countermeasures, hypokinesia was found to impact the female reproductive system developing clinical symptoms of deficiency of the menstrual lutein phase and giving rise to small inclusions of functional fluids in the ovaries.

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The incidence of llanol dosage free and integrated hepatitis B virus (HBV) in various human tissues is discussed. However, the subsampling factors are upper-bounded by the number of parallel channels. The second class of interfaces (class B) with more polar residues than core and surface is shown. Protective efficacy of intravenous transplantation of adipose-derived stem cells for the prevention of radiation-induced salivary gland damage.

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Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. An external drain was placed near the aldazide pfizer products site of the leak for 2 weeks. Although peg formation is seen specifically in cucurbitaceous seedlings, it involves graviperception, auxin transport and redistribution and cytoskeletal modification for controlling cell growth polarity. To compare how quickly children with autism spectrum disorder (ASD) acquired manual signs, picture exchange, and an iPad/iPod-based speech-generating device (SGD) and to compare if children showed a preference for one of these options.

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Much more research will be needed, however, before meteorite impact is established as a general causal factor in extinction. Thus, even though embryonic primordia initially have a random axial orientation, conjoined larvae usually possess a nupentin information on common orientation due to reorientation during germband extension. Human embryonic stem cells (hESCs) are pluripotent and provide a unique, unlimited resource for human hepatocytes. This clinical randomized study was conducted in Ayatollah Kashani Center in Isfahan from Nov 2010 to Nov 2011.

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The presence of periosteal reaction on radiographs at the site of clinical symptoms is predictive of a high-grade stress injury by MRI criteria. Advocates should actively seek out these innovations, campaign for the financial gains from these innovations to benefit their originators and their countries, and find ways to develop and distribute them locally as paroxetine mesylate vs paroxetine hydrochloride side well as globally.

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Tumor HPV status is a strong and independent prognostic factor for survival among patients with OPSCC. Focusing on the challenges of the incidentalome, the large set of incidental findings potentially generated through genotyping, the paper argues that provisional approaches to managing incidental findings may be implemented if necessary to allow benefits of pharmacogenomic testing to lansoprazole vs omeprazole vs ranitidine tablets be realized in the clinical setting. Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 111In-labeled platelets and homologous 51Cr-labeled platelets differ. Epidemiology of Brucella infection in the human, livestock and wildlife interface in the Katavi-Rukwa ecosystem, Tanzania.