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Holoprosencephaly is the most common structural malformation of the forebrain in humans and has a complex etiology including chromosomal aberrations, single gene mutations and environmental components. Clinical predictors of temporomandibular joint arthritis in juvenile idiopathic arthritis: A systematic literature review. Heavy metal contamination has become a worldwide environmental concern due to its toxicity, non-degradability and food-chain bioaccumulation.

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The 90th anniversary year of the All-Russian Research Institute of Railway Hygiene Optical detection of x-ray-absorption spectra: Sodium salicylate as an example.

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A custody and placement evaluation of an infant with a psychotic, mentally retarded mother. Historically, nephrectomy for autosomal dominant polycystic kidney disease was performed by an open technique. MicroRNAs have been detected in blood, saliva, stool, breast milk, urine, bile etc. Also, previous methods for discovering hidden common causes either do not handle multi-step time delays or restrict that the parents of hidden common causes are not observed genes. Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.

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Furthermore, the DNA glycosylase activity of cells carrying the Cys/Cys alleles is more sensitive to inactivation by oxidizing agents when compared with that of the Ser/Ser cells. Dissociation constants of functional amino groups of the analyzed sorbents were determined by potentiometric titration. A comprehensive search was undertaken using the PubMed Advanced Search Builder. Determinants of channel gating located in the N-terminal extracellular domain of nicotinic alpha7 receptor.

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Revisiting keratoconus diagnosis and progression classification based on evaluation of corneal asymmetry indices, derived from Scheimpflug imaging in keratoconic and suspect cases. Experiment 2 supported this hypothesis by providing evidence of self-generated elaborations. A clinical study on the effects and mechanism of xuebijing injection in severe pneumonia patients. More importantly, their tubular structure helps the transport of ions through the crystal.

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miRNAmeConverter: an R/bioconductor package for translating mature miRNA names to different miRBase versions. Post-endoscopic use of high-dose intravenous PPI can reduce the risk of rebleeding and further interventions such as repeated endoscopy and surgery. Intensity was modeled as a function of distance between the focus and the center of the cluster of foci using a Gaussian kernel. We predict that the Berry phase transition of the nuclear spin system take place in a quasicyclic evolution for some initial states, resulting in that the evolving memory of nuclear spin polarization is kept in terms of the Berry phase. The asthma of more than one-third of elderly individuals with this condition was poorly controlled, and a history of pulmonary tuberculosis may have contributed to this outcome.

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Droplet charging characteristics depending on the geometry of charging electrodes have been investigated experimentally and numerically. Succinylcholine (1 mg/kg) aggravates the heart depressant actions of the tested drugs, while the intubation of the trachea produces sometimes a serious pressor response which can not be always blocked by prior administration of a low dose (0.1 mg i.v.) Fentanyl. Cardiac and subcutaneous ATDPCs were doubly transduced with lentiviral vectors for the expression of chimerical bioluminescent-fluorescent reporters driven by constitutively active and tissue-specific promoters (cardiac and endothelial for cTnI and PECAM-1, respectively). Further, the combination of catheter replacement and imidazole anti-fungal therapy appears to be curative in this animal model, and suggests that by using this protocol, discontinuation of peritoneal dialysis may not be necessary.

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Moxifloxacin for Buruli ulcer/HIV coinfected patients: kill two birds with one stone? Bacteriocin activity was not eliminated by exposure to high temperatures or catalase but was destroyed by exposure to the proteolytic enzymes proteinase K and trypsin. In this study we vaccinated BALB/c mice with rBCG-EgG1Y162, and then detected the level of IgG and IgE specifically against the recombinant protein by ELISA, rBCG-EgG1Y162 induced strong and specific cellular and humoral immune responses. The extended temporoparietal fascia flap is a logical variation of previously accepted extended free tissue transfers, which are unique in that the recipient and donor vessels are identical.

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Compared with placebo, dapagliflozin 5 and 10 mg demonstrated clinically and statistically significant improvements in HbA1c levels after 24 weeks of treatment. Physiologic effects of increasing hemoglobin concentration in left-to-right shunting in infants with ventricular septal defects. The regional health authorities have a key role in establishing electronic systems that make relevant outcome measurements available in a seamless way for clinicians as well as for patients, and by contributing to a culture where quality and outcome are valued and given priority. Purified PRP, which exhibits no DNA polymerase activity, completely restores the activity of DNA polymerase alpha on templates with low primer to template ratios such as heat-denaturated DNA, poly(dA)-oligo(dT), and singly primed M13 single-stranded DNA. The magnitude of electrolyte and water transport was found to differ in vitro and in vivo.

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To review the published scientific literature for studies quantifying or examining factors associated with the attrition of undergraduate nursing students in pre-registration programs and the retention of graduate nurses in the workforce. The article presents data concerning the surgeons who worked at the Leningrad Medical Institute for Postgraduate Training and achievements of surgical departments during 100 years of existence of the institute. The virus was isolated from affected humans, horses, and from the uterine fluids of a grey-headed fruit bat (pteropus poliocephalus). Endocrine disorders among long-term survivors of childhood head and neck rhabdomyosarcoma.

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Polymorphism in the restriction fragments length of human DNA sequences linked to mucoviscidosis locus was studied in the healthy control group and in the families affected by mucoviscidosis. Investigating the effects of Capparis Spinosa on hepatic gluconeogenesis and lipid content in streptozotocin-induced diabetic rats.

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The coupling of gene expression with the mechanics of cell movement is important for formation of both the trophectoderm and the endoderm. Disuse-induced muscle atrophy is a major concern in aging, in neuromuscular diseases, post-traumatic injury and in microgravity life sciences affecting health and fitness also of crew members in spaceflight. The degree of angiogenesis is determined by the balance between the positive and negative regulating molecules that are released by tumor and host cells in the microenvironment. Median post-void residual volume (PVR) was below 20 ml in all groups.

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Restless sleep was associated with an increased risk of obesity, T2DM, and CVD. A reappraisal of Theroteinus (Haramiyida, Mammaliaformes) from the Upper Triassic of Saint-Nicolas-de-Port (France). It also compares medical income in Canada to that in the United States. The clinical course is generally benign, and current treatment aims to control the various clinical manifestations of this obscure disease process.

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Tomato (Lycopersicon esculentum, Mill.) roots were analyzed during growth on agar plates. T4 increased N and P wave amplitudes and N wave area under the curve, but reduced P wave duration and N-P interval, suggesting that T4 exerts both excitatory and synchronizing effects on DH interneurons in less than 300 s, thus, providing evidence of nongenomic effects of T4 on DH. Social competence in schizophrenia: premorbid adjustment, social skill, and domains of functioning. SR-BI may directly mediate these effects by increasing hepatic HDL cholesterol uptake or by increasing cholesterol secretion into bile, or both.

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Precocious pseudo-puberty in granulosa cell tumor in children less than 1 year old. Four hundred and twenty-three patients with histologically confirmed colorectal cancer who underwent surgery with curative intent between 1997 and 2007 were included.

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He developed rapidly progressive graft dysfunction 3 years later. We identified 456 patients from a prospective registry who were treated surgically for localized RCC between 2002 and 2014.

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Proteins in complexes are still under-represented in the structural databases and in particular many proteins involved in transient complexes are still to be crystallized. This study was conducted to detect predictive factors affecting the success of microTESE. Capsulotomy was performed in all eye specimens using manual CCC, a femtosecond laser (LenSx, Alcon, Fort Worth, TX), or an automated PPC device (Zepto, Mynosys Inc., Fremont, CA).

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To study the effects of acute hypoxia and intermittent hypoxic acclimatization on cardiac systolic and diastolic functions in rats. Inadvertent injection of sodium hypochlorite into the maxillary sinus. To get the stable values of compensatory parameters, the duration of the infusion test must at least double the inflexion time of the test curve. Microvascular complications after free-flap breast reconstructions are potentially devastating problems that can increase patient morbidity and lead to flap loss.

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Community mobilisation was viewed as essential to ensure the effectiveness and sustainability of CBR. These results suggest that the central components of heterochromatin play roles including repressing differentiation genes in Drosophila male GSC maintenance. There are several histologic subtypes, which can be difficult to distinguish.

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Symptom profiles in pediatric obsessive-compulsive disorder (OCD): the effects of comorbid grooming conditions. Numerical results are given for the exemplary application of CNR Q to decentralized resource control in heterogeneous wireless networks.

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Proliferative responses of circulating human NK cells: delineation of a unique pathway involving both direct and helper signals. Oxygen is therefore considered to be a drug requiring a medical prescription and is subject to any law that covers its use and prescription. Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model.

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Stoichiometry of calcium binding to gamma-carboxyglutamic acid in prothrombin. Part two: moving toward making the best possible decision: defining conditions for putting decisions into practice

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We investigated the combined effects of intra-amniotic lipopolysaccharide (LPS) and maternal betamethasone (BMZ) on alveolarization using a newborn rat model. ITPC maxima were determined by visual inspection and these results were compared to results of multi-way factor analyses.

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A single-center cohort of 3646 patients underwent inpatient vascular surgery from January 1, 2000, to November 30, 2010, at a tertiary care teaching hospital. Randomized Phase III Trial of Standard Therapy Plus Low Molecular Weight Heparin in Patients With Lung Cancer: FRAGMATIC Trial. Fetal growth rate decreased progressively from about 5.9 mm per day between 90 and 111 days of gestation to about 3.6 mm per day by 130 days.

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Achieving an efficient and effective logistic preparation and response is one of the key elements in mitigating the impact of such events, but the establishment of mechanisms to deliver an appropriately integrated civil-military approach remains elusive. We show empirical evidence in Enterobacteria that neighboring genomic regions have similar trees. Doublet potentiation in the triceps surae is limited by series compliance and dynamic fascicle behavior. Origin of Unusual Excitonic Absorption and Emission from Colloidal Ag2S Nanocrystals: Ultrafast Photophysics and Solar Cell.

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How many Americans lack outside sources of payment for major health care costs? The clinical and laboratory features of these patients were then reviewed, showing that only 11 displayed clinical manifestations of a drug interaction. The last manuscript described a cost-effectiveness model that compared pregabalin versus levetiracetam use for the treatment of refractory partial epilepsy. In this study we assessed acute-phase reactants (APR) and immune response status (humoral and cellular) in active and inactive untreated AS patients categorized according to different activation/remission criteria. Atrial fibrillation (AF) is associated with increased morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM).

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Patients diagnosed with pancreatic adenocarcinoma between July 2009 and June 2011 were identified by cancer registries, and detailed clinical data were collected from medical records. X-ray diffraction patterns of amorphous griseofulvin were repeatedly measured every 20 h. Advances in Vascular Hyporeactivity After Shock: The Mechanisms and Managements. The use of monoclonal and polyspecific antibodies in the IgE sandwich ELISA. GR antagonism can potentiate age-related sleep pattern alterations and further support the role of impaired GR signaling in age-related changes in sleep architecture.

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The relation of perception of decline to actual decline was also examined. Our previous study demonstrated that pretreatment with electroacupuncture (EA) induces rapid tolerance to focal cerebral ischemia.

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No matter how popular university and private hospitals were in our regional capital, general hospitals played a proximity role. The patient had a difficult post procedure course that was successfully medically managed.

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The OGC were characterized by benign-appearing nuclei, whereas the MC had atypical nuclei with a considerable number of mitoses. Monitoring of urea and potassium by reverse iontophoresis in vitro.

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The aim of the present study was to evaluate the effect of an acute physical activity upon K complex, PLM, and myoclonus during sleep in individuals who were paraplegic. Echocardiography with color flow mapping failed to demonstrate the fistula on three occasions, including one study performed after angiographic demonstration of the fistula site.

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The altered histoarchitecture of heart and kidney tissue due to DXR treatment were also improved with HAELA. The relation between postoperative pulmonary complications and risk factors was investigated. These data indicate that the spectrum of HC includes patients who have a potentially arrhythmogenic left ventricular substrate but who have no evidence of left ventricular hypertrophy. Alpha 2-adrenoceptor blockade attenuates feeding behavior induced by neuropeptide Y and epinephrine. Even in a small number of patients, isoflurane induced an elevation of serum levels of liver enzymes more frequently than did sevoflurane three to 14 days after anaesthesia.

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However, xenografts are highly heterogeneous structures, and therefore it is sometimes difficult to evaluate the effects of the compounds on tumor metabolism. However, it was inhibited by IgG from normal adults and from the same TTP patient after recovery. In the review the essential features of system regulation of mammary blood flow, substrate supply, uptake and utilization by cellular metabolism and for milk component synthesis are considered, with emphasis on productive ruminants (cows and goats). Randomized, controlled histologic and histomorphometric evaluation of implants with nanometer-scale calcium phosphate added to the dual acid-etched surface in the human posterior maxilla. A 44-year-old man was admitted to our hospital because of right nasal obstruction.

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Sustained protection against photoreceptor degeneration in tubby mice by intravitreal injection of nanoceria. Here we show that the overexpressed thyroid hormone receptor c-erbA effectively modulates erythroid differentiation and erythrocyte-specific gene expression in a T3-dependent fashion, when introduced into erythroid cells via a retrovirus. To explore and compare the impact of generic substitution (GS) on the turnover and gross margin per cent of pharmaceutical companies representing mainly original or generic products in Finland. Our data demonstrate that MT1-MMP proteolysis of BRCA2 regulates the abundance of BRCA2 on centrosomes.

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Disagreement between pulse contour analysis and transpulmonary thermodilution for cardiac output monitoring after routine therapeutic interventions in ICU patients with acute circulatory failure. The risk of VTE varies considerably across patient age and increases most dramatically at age 16 years, after a smaller increase at age 13 years.

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These findings suggest that the retina is a good model system for investigating tau-driven neurodegeneration and for assessing potential pharmacological modifiers for tauopathies. Sequence analysis of full length cDNA clones corresponding to the MCM3, 6 and 7 fragment proves the existence of six MCM genes in Drosophila melanogaster. Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy: using multiple band frequency analysis. 6 patients, 4 men and 2 women, aged 38 to 60 years, were hospitalised for chest pain on effort, labelled as angina. However, while hyperaemic flow falls significantly, resting coronary flow is maintained by compensatory reduction of MVR, demonstrating coronary auto-regulation.

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They are observed with a particular frequency in bronchiectasis. Cardiotoxin III Inhibits Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition and Suppresses Invasion of MDA-MB-231 Cells. Furthermore, pre-treatment of Arabidopsis leaves with CNF effectively reduced pathogen infection by both the fungus Alternaria brassicicola and the bacterium Pseudomonas syringae pv.