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Topiramate
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Topiramate

Topiramate is an anticonvulsant drug used to treat epilepsy in both children and adults. In children it is also indicated for treatment of Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). It is also Food and Drug Administration (FDA) approved, and now most frequently prescribed for, the prevention of migraines. It has been used by psychiatrists to treat bipolar disorder, although it is not FDA approved for this purpose and such use is somewhat controversial. This drug has been investigated for use in treatment of obesity, especially to aid in the reduction of binge eating, and also as a possible treatment for alcoholism.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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We examine the question of coexistence of three microbial populations competing for two complementary rate-limiting substrates in configurations of interconnected chemostats. All patients admitted through the emergency department who received an antibiotic therapy within 24 hours of admission were included. Superfluid compressibility and the inertial mass of a moving singularity. However, foci of severely dysplastic epithelium usually showed a positive reaction. The authors conducted a retrospective observational study of 12 patients who underwent rotationplasty of the knee and received prosthetic care at this institution.

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Extremely high myoglobin plasma concentrations producing hook effect in a critically ill patient. This study sought to describe the operative technique and clinical outcomes in a series of 57 patients with trigeminal neuralgia treated with endoscopic vascular decompression (EVD) alone without the use of microscopy at any point. This was a cross-sectional study of baseline data from a representative sample of patients with COPD enrolled in a clinical trial.

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Since this method is microscopy based, it allows one to quantitate Gag across the cytoplasm, from the nuclear periphery to plasma membrane, at the single-cell level. Trypanosoma brucei gambiense infection is widely considered an anthroponosis, although it has also been found in wild and domestic animals. It forms a 1:1 complex with tissue type plasminogen activator, which retains activity detectable under the analytical conditions used. As such, we investigated the role of PAR-2 in airway neutrophil recruitment, activation and cytokine production following allergen exposure.

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Despite the high rate of recurrent venous thrombosis after discontinuation of anticoagulation, there are currently insufficient data to recommend indefinite warfarin therapy. Birds with combined baroreceptor and chemoreceptor denervation exhibited the same degree of bradycardia as chemoreceptor denervates, and arterial blood pressure rose spectacularly during a dive.

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Although there are many targets of oxidants, this review emphasizes protein oxidation with a focus on an important group of redox-sensitive enzymes, the thiol-proteases. This method should be especially useful for drug screening due to the small sample volume and high information density. Subjects with chronic kidney disease (CKD) have an increased risk of developing coronary atherosclerosis. Bacterial communities associated with Porites white patch syndrome (PWPS) on three western Indian Ocean (WIO) coral reefs. We generate selection corrected health profiles using an inverse probability weighting procedure and find that attrition is indeed not random: older, poorer and unhealthier individuals are significantly more likely not to survive the next year and to be admitted to an institution.

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The kdr and metabolic resistance both contributed to pyrethroid resistance in the Cx. The results revealed that knockdown of sCLU by OGX-011 resulted in a significant increase in the expression of E-cadherin and a decrease in matrix metalloproteinase-2 (MMP-2) gene transcription.

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To determine the frequency and association of Vitamin D deficiency in patients with tuberculosis. A retrospective chart review of all patients in police custody with K-9 dog bites who presented to the Jail Ward ED between January 1, 1988, and December 31, 1995, was conducted. Key differences in the sequences and structures of hMS and MetH activation domains are recognized and include a major reorientation of an extended 3(10)-containing loop in the human protein. Subcellular fractionation of keratinocytes expressing E2Y131A showed a marked change in the localization of the protein.

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Sleep performs an essential restorative function and facilitates memory consolidation in humans. Beclamide (50-250 mg kg-1 p.o.) caused an overall dose-dependent increase in the attack onset latency, a reduction in the percentage of animals attacking and the mean number of attacks/animal for this model of aggression.

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Effects on serum lipids, electrolytes, liver enzymes, and blood pressure. Some countries traditionally have long periods of postpartum female sexual abstinence, accepted male extramarital relations over the period, and large age differences between spouses. The current data concerning the relationship between tricyclic plasma levels and their clinical responses indicate that there is a therapeutic window at 50-150 ng/ml for the secondary derivatives (nortriptyline and desipramine). Single-domain antibodies (sdAbs), also known as nanobodies or VHHs, are characterized by high stability and solubility, thus maintaining the affinity and therapeutic value provided by conventional antibodies.

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We chose the measures we thought were most relevant for perinatal research and had been linked most strongly to perinatal outcomes. Two new point mutations at A2062 associated with resistance to 16-membered macrolide antibiotics in mutant strains of Mycoplasma hominis.

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H2B histone mRNA was repressed in proportion to the concentration of DMSO. aureus was also significantly inhibited by nine ketolide compounds, suggesting that they were not inducers of methylase gene expression.

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The European Study Group on MRD detection in ALL (ESG-MRD-ALL), consisting of 30 MRD-PCR laboratories worldwide, has developed guidelines for the interpretation of real-time quantitative PCR-based MRD data. We measured MR in a cued-response task using electromyography (EMG) while participants squeezed a rubber ball hard or softly in response to colored words.

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Quantification of photosensitizer concentration in tissue improves the planning and, subsequently, the outcome of photodynamic therapy. Embryonic development of the eye, including the cornea, depends on the appearance and steady maintenance of intraocular pressure. The potential dose of PM(2.5) was estimated using the Monte Carlo simulation, stratifying the population by age, gender, asthma and Body Mass Index (BMI). Conference Report: THE SIXTH INTERNATIONAL MEETING ON CHEMICAL SENSORS Gaithersburg, MD July 22-25, 1996. Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to hypogonadism.

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Timing and role of p53 gene mutation in the recurrence of glioma. Nrf2 heterodimerizes with small Maf (sMaf) proteins and binds to antioxidant response elements (AREs) to activate a battery of cytoprotective genes.

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Laparoscopic versus open gastric resections for gastric gastrointestinal stromal tumors: a meta-analysis. Thermal resistance again developed in both tissues following the second heat treatment, which was given 7 or 8 days after the first heat treatment. This immuno-quantified solid phase assay combines the use of an immobilized C-terminal biotinylated peptide as substrate, a crude enzyme preparation, and a highly specific antiserum elicited against the C-terminal product of the enzyme reaction.

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Both type I and type II reactional patients showed significantly higher serum IFN-gamma, IL-2R, and IL-1beta, in addition to IL-10 in type II reactional patients, compared with nonreactional leprosy patients. Current clinical attire requirements for dental hygiene students. Genetic variance and heritability were estimated for individual skinfold thicknesses, the sum of three skinfolds (SUMSF) and BM, separately by age classes for both sexes. Benefits of Heart Rate Slowing With Ivabradine in Patients With Systolic Heart Failure and Coronary Artery Disease.

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Chronic hepatitis C: grading, staging, and searching for reliable predictors of outcome. Left ventricular diastolic dysfunction: early diastolic relaxation and late diastolic compliance. Axial pattern bilobed flap for the reconstruction of the midline forehead defects. Early BKV positivity of urine and blood indicates later BKV nephropathy.

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Minimum 5-year follow-up results of skipped pedicle screw fixation for flexible idiopathic scoliosis. This supports a role for such particles in the adverse health effects of PM(10). Especially, the attitude towards splenectomies should be changed in favor of spleen-preserving surgical procedures. The findings show that social determinants of health, including both socio-economic and household characteristics, are associated with Inuit child health. Ribosome-bound nascent polypeptides are partially resistant to proteolysis at 0 degrees , although they are totally digested at 37 degrees or when the ribosomal subunit structure is disrupted by other means.

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The infants with extremely low birth weight (ELBW) (body weight less than or equal to 1000 g) showed precipitous declines of total T4 and, to a lesser extent, of FT4 concentrations at 1 and 2 weeks of age. This case report describes the occurrence of tension pneumocephalus after surgical drainage of bilateral chronic subdural hematoma. Noninvasive aortic blood flow measurement using an intraesophageal probe.

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Compared with the enhanced MDCT, non-enhanced MRI and enhanced MRI provide slightly superior diagnostic efficacy for the preoperative T staging of NSCLC. The Rijnmond Collective Cardiology Research (CCR) registry is an ongoing prospective, observational study in the Netherlands that aims to enrol 4000 patients with ACS. In vivo assay identified that the knockdown of Gab1 interfered with the tumor mass formation. Demographic information, results of laboratory examinations, and computed tomography (CT) presentations were recorded and analyzed to achieve a distinguishing model/system for malignancy.

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Avian-pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis, a disease that affects all facets of poultry production worldwide, resulting in multimillion dollar losses annually. Although the need for a more patient-centered approach in clinical practice is widely acknowledged, empirical evidence regarding patient preferences for diagnostic modalities in epilepsy is missing.

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In addition, in sporadic PD, normal alpha-synuclein shows an increased tendency to self-aggregate. A novel noninvasive three-dimensional volumetric analysis for fat-graft survival in facial recontouring using the 3L and 3M technique. Nondiscrimination on the basis of age in programs or activities receiving federal financial assistance from HEW: proposed rules. Transition metal-catalyzed methods that are both selective and economical for formation of cyclic structures, of great interest for biological purposes, represent an important starting point for this long-term goal. This multicentre phase II trial assessed the safety and efficacy of chemoselection with docetaxel plus cisplatin and 5-fluorouracil (DCF) induction chemotherapy (ICT) and subsequent conversion surgery (CS) for initially unresectable locally advanced SCC of the oesophagus.

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Clinical outcomes of patients with isolated femoral shaft fractures treated with S.I.G.N interlock nails versus Cannulated Interlock Intramedullary nails. Future research on placebo effects should focus on whether awareness of placebo effects can disable these effects and whether subjects can control their own placebo effects. Videourodynamic studies were performed at baseline and after treatment. Further complication arises in that seizures do not occur with a single type of dynamics but as many different phenotypes and genotypes with a range of patterns, synchronous oscillations, and time courses. These advances have fostered innovative models and informative experiments in bacteria since this topic was last reviewed.

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Insulin and glucagon secretion in swimming mice: effects of autonomic receptor antagonism. Aberrant tau protein accumulation drives neurofibrillary tangle (NFT) formation in several neurodegenerative diseases. Early impairment of standing on tip-toe with retention of the ability to stand on the heels was conspicuous. To estimate the number of coronary heart disease (CHD) events arising from the primary and secondary prevention populations of middle-aged Australian men, and the potential impact in each setting of lipid-lowering therapy on death from CHD.

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Intracerebral haematoma following spinal anaesthesia for caesarean section: case report. Fifty-nine patients (62 ears) with tympanosclerosis were treated by ossicular chain reconstruction. Burn serum can initiate the synthesis and release of adhesion molecules in endothelial cells through activation of NF-kappaB, indicating that NF-kappaB plays an important role in the process of burn serum induced endothelial secretion of adhesion molecules. A methodology is provided to determine how much removable surface contamination can be detected on a large area wipe by surveying the wipe with a portable survey instrument. Aquatic Hemiptera (Heteroptera) of Kazakhstan, with notes on life history, ecology and distribution.

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Attention to enablers and barriers is important for successful implementation. To evaluate their preventive effects, well-controlled trials including follow-up assessments are necessary. This study assessed the long-term efficacy of EECP (Enhanced External Counterpulsation) in Turkish (TR) patients initially and compared these results with the United States (US) in a real world setting. We constructed and characterized a number of insertion, deletion and point mutations in the regions of ail predicted to encode the cell surface loops. Interpreting the effectiveness of involuntary outpatient commitment: a conceptual model.

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Matrix-fortified calibration was performed to compensate for the matrix effect and loss in sample preparation. Suppression of Lewis carcinoma metastasis in mice by an interferon-inducing vasodilator curantil Semiclassical approach to Dirac operators in external gauge fields corresponding to supersymmetric quantum systems.

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Attempts to prevent oral mucositis have included oral cryotherapy, which has been shown to reduce mucositis, but there is a lack of knowledge concerning the effect of oral cryotherapy on opioid use by reducing the mucositis for patients treated with myeloablative therapy before bone marrow transplantation (BMT). The last few years have seen a phenomenal increase in the prevalence of chronic kidney disease (CKD). Genital infections and urinary tract infections were more common with dapagliflozin. Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia.

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Ideally, ABO-identical cardiac grafts should be used but transplantating using ABO compatible types allows reduced waiting times among recipients with rarer types without a significant increase in hyperacute rejection. A tool for determining duration of mortality events in archaeological assemblages using extant ungulate microwear. To determine whether removal of the internal limiting membrane (ILM) during macular hole (MH) surgery alters the retinal function.

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We observe that not just symmetric, but also asymmetric appearing dimers exhibit flip-flop motion. Ultrastructural demonstration of intracellular bacteria in xanthogranulomatous pyelonephritis.

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The contamination of clinical specimens material, obtained from patients with otolaryngology inflammatory processes and purulent meningitides in the Moscow region, has been studied. Partition behavior of eight small organic compounds and six proteins was examined in poly(ethylene glycol)-8000-sodium sulfate aqueous two-phase systems containing 0.215M NaCl and 0.5M osmolyte (sorbitol, sucrose, TMAO) and poly(ethylene glycol)-10000-sodium sulfate-0.215M NaCl system, all in 0.01M sodium phosphate buffer, pH 6.8.

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A simple scheme was developed to identify the most likely hydrolysis mechanism based on experimental data. We evaluated whether subjects without visible superior palpebral crease persistently lifted their eyelids more than subjects with visible superior palpebral crease, whether the presence of persistently lifted eyebrow in primary gaze affected the relative height of the supraorbital margin in coronal view 3-dimensional computed tomography imaging, and whether the shape of the supraorbital margin in the coronal view affected that in the sagittal view 3-dimensional computed tomography imaging.

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The mean disease duration and follow-up time was 2 years (median 1 year, range 0.5-8 years) and 3.57 years (median 2 years, range 0.5-14.5 years), respectively.The values of all the analyzed parameters including TI, PI, AT/ET, PAP, FVC and DLCO were found to be within normal ranges in all the patients tested, confirming an uncommonness of cardiopulmonary involvement in patients with juvenile scleroderma. With increasing severity of uraemia, neutrophils from uraemic patients showed progressive impairment of phagocytic ability. Nursing care should focus on helping individuals to look after themselves, engage in self-care action for conserving their health and lives, recover from illness and confront its consequences. The classification takes into account intraorganic and extraorganic location of LFL, and marks it by special letter indices. On microscopy, the appendix showed acute appendicitis along with a Cave-Wallbridge type A duplication.

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These parameters can be used to model emission spectra from PAH cations and cations of larger PAHs, which are better candidate carriers of the UIRs. This study investigated the clinical features which could serve as markers to identify subfertile men with antisperm antibodies including age, duration of infertility, history of abdominal or perineal surgery and previous genital trauma. We have measured rDNA transcriptional activity in different cell lines which either lack or overexpress p53 and demonstrate that wild-type but not mutant p53 inhibits cellular pre-rRNA synthesis.

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A single-factor variance analysis was used to find the correlation between professional delay phentermine topiramate cost and other possible related clinical factors. The effects of constant light and constant darkness on the pineal organ of the goldfish, Carassius auratus. Global cardiac function is commonly assessed quantitatively by post processing tools that calculate global EF. To evaluate the structure and processes of care of neonatal intensive care units (NICU) providing health care to neonates with respiratory insufficiency, and financed by Seguro Popular.

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Employer perspectives on the preferred provider organization concept. Study of DNA methylation digene tablet composition tester patterns of imprinted genes in children born after assisted reproductive technologies reveals no imprinting errors: A pilot study.

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No change of beta-hexosaminidase activity was found after angiography with iohexol, while there was a significant increase after examination with meglumine metrizoate. Ethnicity was found to be associated with the use of health care after controlling for health lansazol 30 mg fiyata status as an indicator for need. Surgical specialties scored substantially higher than general surgical studies. There is substantial agreement between OMSs and c-PRSs regarding the management of ZMC fractures and associated orbital floor injuries.

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Urinary volume and contents of frusemide and sodium were measured in samples collected over 10 h. We previously reported abnormalities in circulating B cells in patients with chronic granulomatous disease (CGD) and those with HIV infection. The serum AGE levels measured by the new enzyme-linked immunosorbent assay reflected the severity of glomerulopathy, and, therefore, it may be acyclovir tablets 800 mg dosis dalsy a clinically useful tool for assessing diabetic renal complications. Arthroscopic debridement of acute septic knees may be carried out in pediatric patients, given appropriate equipment and arthroscopic skills. To determine device-associated infection (DAI) rates, and the microbiological and antibiotic resistance profiles of infecting pathogens in our hospital.

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Management and treatment of AF in this rapidly growing population of older patients involve a comprehensive assessment staxyn doses of levothyroxine that includes comorbidities, functional, and social status. On the screening night, oxygen administration did not improve obstructive sleep apnea, but did improve oxygenation. Electronic properties of superconducting LuNi2B2C and related boride carbide phases.

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this preliminary study reports by the first time the positive influence of the OLE assayed in the regulation of the hypertension, LDL lag time and blood lipid profile. Although observation is the best form of therapy for patients with asymptomatic gallstones, surgical management offers the least risk and greatest benefit to patients with symptomatic disease. On the other hand external calcium antipsychotic drugs quetiapine did not alter significantly the synthesis of either products from exogenous arachidonic acid and the total conversion of the substrate was unchanged. Diagnostic performance of fluorine 18 fluorodeoxyglucose positron emission tomography imaging for detection of primary lesion and staging of endometrial cancer patients: systematic review and meta-analysis of the literature.

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BEFORE THE 1960s, adult mammalian neurogenesis was conceptually unimaginable. We report the first case of plexiform fibromyxoma originating in the esophagus, emphasize its occurrence in pediatric patients, and review the related literature. Experimental infections, using a fluorescent marker, of two elasmobranch species by unciliated larvae of Branchotenthes octohamatus (Monogenea: Hexabothriidae): invasion route, host specificity and post-larval development. Pseudoaneurysm after penetrating trauma in children and adolescents. We suggest that an awareness of these effects among physicians and patients could help reduce bias and improve the epitec medicine for diarrhea quality of medical decision making.

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Comparative analysis of trauma characteristics between elderly and superelderly. Seven observers assessed the examinations with the aid of reference images and written diagnostic cues for three disc diagnoses. The staining of tau protein and terminal deoxynucleotidyl transferase-mediated dUTP-biotin trimesulf sulfamethoxazole drug in situ nick end labeling (TUNEL) did not show any positive signals in the control brain, but showed positive signals after ischemia with a peak at 24 h and 3 days, respectively.

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Dielectric Investigation of Parylene D Thin Films: Relaxation and Conduction Mechanisms. In situ hybridization and immunohistochemistry studies show that levox 500 side effects Gscl is expressed in the pons region of the developing central nervous system and primordial germ cells. We used PHA helpdesk interaction data to first ascertain the information requirements of those getting in contact with the service, and secondly to examine the communicative behaviour of the PHA, with a view to improving the quality of communication strategies.

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Multiple region whole-exome sequencing reveals dramatically evolving intratumor genomic heterogeneity in esophageal squamous cell carcinoma. During this same time period, the mRNA levels for alpha-MHC declined by more than half, whereas beta-MHC mRNA levels remained low and unchanged. Chronic infection of the prostate with gram-negative bacterial pathogens (mainly coliforms) is a common cause of recurrent urinary tract infections in men. -AAGAG- nucleosomes do not contain D1 protein, but appear to be sertima tablet reviews enriched in ubiquitinated core histone H2A. These findings implicate mechanisms involving pertussis toxin sensitive G-proteins in modulating some behavioral and physiological effects of ethanol.

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Two single nucleotide missense polymorphisms rs7935564A/G (SNP-1) and rs1063303C/G (SNP-2) characterize the coding sequence of human TRIM22 gene. The expression of three ferritins genes (PvFer1, PvFer2 and PvFer3), determined by quantitative PCR, indicated a difference in the expression kinetics among the cultivars. Wolff algorithm optilast dosage calculations and anisotropic continuous-spin models: An application to the spin-van der Waals model.