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Duraject (Dapoxetine)
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Dapoxetine

Duraject a selective serotonin reuptake inhibitor is a new chemical entity for the treatment of premature ejaculation. Since no systematic studies on design and development of Duraject hydrochloride tablets are available in literature, we propose to develop a suitable formulation to characterize in vitro release profile of Duraject hydrochloride. The aim of the present study was to formulate various formulations of immediate release tablets of Duraject Hydrochloride using different excipients by direct compression and wet granulation method. The granules and tablets of Duraject HCl were evaluated for various pre and post compression parameters like Angle of repose, Compressibility index, Hausner's ratio, Tablet hardness, Thickness, Friability, and chemical parameters. Punches of different size were used to obtain the desired shape, ease of swallowing of tablets, to improve aesthetic value in terms of appearance and shape of tablets. To match dissolution profile of test formulation with innovator, drug particle size is reduced from D 90-158 µ to D 90-45 µ, which resulted in an increased surface area exposed to the dissolution medium. Final formulation was evaluated for multimedia dissolution in three different media and dissolution data was found satisfactory. Accelerated stability studies conducted for 2 Months at 40°C and 75% RH and were found within specification.

Other names for this medication:
Dapoxetine, Actinex, Aczone, Dapoxetin, Dapoxetina, Dapsone, Dejac, Duraject, Duralast, Poxet, Priligy, Viglast, Westoxetin, Xydar,

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The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Activation of caspase-3 by interferon alpha causes interleukin-16 secretion but fails to modulate activation induced cell death.

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Electronic transport properties of giant-magnetoresistance Fe/Cr multilayers. The aim of this study was to validate this scoring system in a large population of preterm infants across a range of gestational ages. Minima hopping is improved with a softening method and a stronger feedback mechanism.

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Treatment for metastatic colorectal cancer (mCRC) commonly involves a fluoropyrimidine-based chemotherapy regimen such as infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) or fluorouracil, leucovorin, and oxaliplatin, often combined with bevacizumab or an epidermal growth factor receptor monoclonal antibody. Effectiveness of pimecrolimus cream for women patients with sensitive skin and its underlying mechanism. Is the addition of a foot ring to the circular external fixator necessary in the treatment of extra-articular distal tibia fractures? Conservation laws and two-dimensional black holes in dilaton gravity. The findings suggest that perceived objective severity and perceived psychological barriers play important role in adapting a desirable health behavior among young adolescents.

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A rare case of congenital mitral insufficiency characterized by six well-demarcated leaflets of mitral valve and annular dilatation is reported. We demonstrate that the microstructural and mechanical properties of bacterial biofilms can be created through colloidal self-assembly of cells and polymers, and thereby link the complex material properties of biofilms to well understood colloidal and polymeric behaviors.

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Significance of gastric mucin in the aetiopathogenesis of chronic duodenal ulcer. The management of refractory benign esophageal stricture, which fails to establish adequate food passage despite multiple dilatation sessions, has been considered challenging. As a continuation of this previous study, in order to characterize the biological function of antibacterial PEAP, we have here examined whether this COOH-terminal fragment is released from stimulated chromaffin cells and whether it could be detected in wound fluids and in polymorphonuclear secretions following cell stimulation. In the first category, without intellectual impairment or major structural brain abnormalities, half of the cases are merosin deficient due to mutations of the laminin alpha 2 chain gene. Autopsy revealed dissemination of tumor cells in the bone marrow, bilateral pleura, and soft tissue around the operated site.

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Evaluation of six different DNA extraction methods for detection of Mycobacterium tuberculosis by means of PCR-IS6110: preliminary study. Effects of dexamethasone on sodium-potassium-chloride cotransport in trabecular meshwork cells. Deuteron production in alpha -nucleus collisions from 200 to 800 MeV per nucleon. Surgery is indicated for symptomatic, enlarging, or large (greater than or equal to 2.5 cm) SAAs as well as any SAA found in women of childbearing age.

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Long-term exposure to ovarian hormones contributes to age-related changes in estrous cyclicity in rodents. Experiments and models have shown how the network frequency depends on excitation of the interneurons, and on the parameters of GABAA-mediated IPSCs between the interneurons (conductance and time course). Transgenic mice expressing fluorescent pericytes (NG2, DsRed) were imaged using a two-channel, adaptive optics scanning laser ophthalmoscope (AOSLO).

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A theoretical model of the dielectric loaded waveguide applicator is compared with models of two other applicators which depend on energy radiated from conductors carrying high frequency current. These results suggest that the formation of soluble erythrocyte cytochrome b5 occurs by proteolytic processing of the membrane-bound form.

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437 school children in the age groups 7, 9, 11, 13 and 15 years participated in this study. Our findings support continuation of the programme, and adopting similar approaches in other countries where HBV transmission is focused in high-risk adults. Cumulative GH levels (GHy) were calculated as a sum of average of GH readings in consecutive years.

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Efficacy of the telephone-based Brief Motivational Intervention for alcohol problems in Brazil. The goal of this review is to describe the technical prerequisites for MR-guided endovascular interventions, to discuss experimental and clinical applications, and to explain safety aspects of this technique.

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We performed a secondary analysis of 124 critically ill, mechanically ventilated patients enrolled in 2 prospective cohort studies where muscle strength testing was performed at a median of 12 days after mechanical ventilation onset. To correlate symptoms, signs, and risk factors with positive wet mounts or cultures for Candida albicans and to develop an algorithm to diagnose vulvovaginal candidiasis. Together with conventional synaptic transmission mechanisms, these molecules are an important element in the trans-cellular communication mediated by synapses. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities. We did not use any date or language restrictions in the electronic searches for trials.

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Protein adsorption was assessed using Western Blot in two hydrophilic and two hydrophobic grafts harvested after three days. We present an algorithm to reconcile a binary gene tree with a nonbinary species tree under a DTLI parsimony criterion. Reactive oxygen species (ROS) regulate bone marrow microenvironment for stem and progenitor cells functions including self-renewal, differentiation, and cell senescence. The purpose of this study was to explore gene expression changes in fatigued men with nonmetastatic prostate cancer receiving localized external beam radiation therapy (EBRT). In contrast, the cGMP response to pro-BNP 1-108 and NT-pro-BNP 1-76 was not significantly greater than no treatment alone.

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