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Regardless of the target compound, the same challenges arise when considering the biofortification of plants with antioxidants, that is the need to modulate endogenous metabolic pathways to increase the production of specific antioxidants without affecting plant growth and development and without collateral effects on other metabolic pathways. The gene encoding this protein, cep-1, promotes DNA damage-induced apoptosis and is required for normal meiotic chromosome segregation in the germ line.

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Secondary outcome measures were isokinetic muscle torque, dynamic function and muscle flexibility, as well as pain level estimations using visual analogue scale (VAS). The occurrence of sustained arrhythmias or the occurence of neurological deficit during the CSM or in the first 24 hours after its end were considered complications of the CSM. Here, the TCE dechlorination rate and reaction products are measured as a function of adsorbed polyelectrolyte mass for three commercially available polyelectrolytes used for NZVI surface modification including poly(styrene sulfonate) (PSS), carboxymethyl cellulose (CMC), and polyaspartate (PAP). Consistently, quantitative PCR and Western blot analysis showed an up-regulation of markers of osteoblast differentiation and bone repair, and a decrease in EGFR expression. Enthoven says his plan would return cost consciousness to health consumer decisions.

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The neuregulins (NRGs) play important roles in animal development and homeostasis, and their deregulation has been linked to diseases such as cancer and schizophrenia. The herpes B virus is a zoonotic agent that is endemic among macaque monkeys only, but can cause fatal encephalomyelitis in humans. Survival using percutaneous cardiopulmonary support after acute myocardial infarction due to occlusion of the left main coronary artery--a report of two cases. These patterns are consistent with a greater burden and increased severity of disease among non-whites under age 65 with Ssc.

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Drug-eluting stents were associated with an increased rate of death, as compared with bare-metal stents. The model is derived from data assessing soil recovery efficiencies in adults using eight different predictive tracer elements. Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study. -30 degrees head down tilt for 45 min was used to simulate short-period weightlessness. Thirty-four randomized clinical trials and observational studies comparing total and subtotal abdominal hysterectomy for benign indications were included.

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These results establish critical roles for Neto auxiliary subunits controlling KARs properties and synaptic incorporation. The phostensin/PP1 complex may play a vital role in modulation of actin rearrangements. Relapse was determined by examination of hospital records, general practice records, patient questionnaire and thyroid function tests.

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(3) Before the end of flowering phase, the peduncle showed a normal negative gravitropic response but afterward it acquired the property to show a positive gravitropic response. Simvastatin improves endothelial function in patents with subclinical hypothyroidism.

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Purification and characterization of rhodobactin: a mixed ligand siderophore from Rhodococcus rhodochrous strain OFS. The tool is called PROGgene and it is available at http://www.compbio.iupui.edu/proggene. At particular risk for feeding problems are infants of premature birth, children with craniofacial anomalies, those with certain genetic syndromes, and those with neurologic involvement.

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Propensity matched or adjusted observational studies with two or more of the interventions of interest (aprotinin, tranexamic acid, epsilon-aminocaproic acid, and no treatment) that were carried out in patients undergoing cardiac surgery. PARADIGM-SHIFT predicts the function of mutations in multiple cancers using pathway impact analysis. A dose-response relationship for the dependence of the cytotoxic activity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on extracellular pH has been established. DESIGN ANALYSIS: of prospectively collected data on a maternity unit database. In addition, TGC was significantly correlated with the accuracy rate of the SDMST.

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Most characterized plant peptides to date acting as small signaling peptides or antimicrobial peptides are derived from nonfunctional precursor proteins. Comparative transcriptional analysis reveals differential gene expression between Sand Daffodil tissues. The cell volume increased tremendously, with the nucleus relatively larger than the cytoplasm as time of treatment increased.

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Hearing loss is becoming an increasingly prevalent problem affecting more than 250 million people worldwide. Fine needle aspiration cytology of metastatic olfactory neuroblastoma. Thus, eating an average of six 440 g cans of this source of baked beans per week, large servings, does not lower the plasma cholesterol when dietary fat is not displaced. HbA1c is a useful predictor of diabetes risk in children and can be used to identify prediabetes in children with other type 2 diabetes risk factors with the same predictive value as FPG and 2hPG. Fluorescein was absorbed rapidly from the RT according to an apparent first-order process the rate constant for which was independent of particle size and possibly regional deposition.

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These data suggest that the unprenylated prelamin A is not toxic to the cells. We consider diffusion processes with a spatially varying diffusivity giving rise to anomalous diffusion. Facilities can demonstrate, to those seeking care, their quality programs by applying for and obtaining certification. Posterior cingulate cortex seeded resting-state functional connectivity was evaluated, and correlation analyses of connectivity strength were performed. To report dermal fat grafting as a novel and effective surgical treatment option in linear scleroderma.

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The framework was derived from an open-pollinated (OP) design composed of plants randomly sampled from a natural population and seeds from each sampled plant, enabling simultaneous estimation of the LD in the natural population and recombination fraction due to allelic co-segregation during meiosis. Leisure-time physical activity seems to increase slightly after retirement, especially moderately intensive physical activity. Minimal contrast use in carotid stenting: avoiding contrast pitfalls.

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Relationship of Circulating Anti-C3b and Anti-C1q IgG to Lupus Nephritis and Its Flare. Human zinc deficiency is thought to be prevalent worldwide, particularly in populations with diets low in zinc and animal protein and high in inhibitors of zinc absorption, such as phytic acid.

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Effects on obese women of the sugar sucrose added to the diet over 28 d: a quasi-randomised, single-blind, controlled trial. (2) Ketone bodies (1 and 4 mM) increase the intracellular concentration and release of glutamate and glutamine, suggesting that inhibition of BCAA transamination does not limit intracellular availability of glutamate for alanine synthesis. Influence of lumbar and hip mobility on the bending stresses acting on the lumbar spine.

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However, these parameters of inflammation induced by synovial fluids from both arthritis were of same degree in intensity. Significant advances in nitrate formulations and delivery systems have been made in providing better bioavailability and sustained plasma concentrations of these drugs. Clinical characteristics of familial generalized anxiety disorder. This observation could contribute to explain the high RBE value of high LET particles. Percolation phenomenon and the study of conductivity, viscosity, and ultrasonic velocity in microemulsions.

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Do patient characteristics influence efficacy and renal outcomes in liver transplant patients receiving everolimus? Double-blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome. Descriptions of the World Health Organization standard methods of assessing susceptibility or resistance in larval and in adult mosquitoes are presented, and the evaluation of their results are discussed. It therefore appears that proteinuria in hypertension is not only a reflection of severity and burden of hypertension, but has some relation with residence.

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The needle aspiration of synovial fluid and steroid injections are commonly-applied activities in daily rheumatology practice. In 2 phase II/III multicenter, randomized, double-blind, placebo-controlled, parallel-group studies, patients were randomized to oral darexaban 15 mg twice daily (bid), darexaban 30 mg bid, oral placebo bid, or subcutaneous enoxaparin 20 mg bid. At similar in vivo treatment conditions (C3H mice with RIF tumors and BALB-C mice with colon-26 tumors) the water-soluble purpurinimide 24 was found to be more effective than the methyl ester analog 8.

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High-power, narrow-bandwidth mid-infrared PPMgLN optical parametric oscillator with a volume Bragg grating. Lungfish de novo transcriptome assembly and differential gene expression analysis reveal notable parallels between lungfish and salamander appendage regeneration, including strong downregulation of muscle proteins and upregulation of oncogenes, developmental genes and lungfish LSGs.

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The present study aimed to determine the prevalence of interictal dysphoric disorder among patients with epilepsy who were followed in two tertiary epilepsy services in Brazil. Effect of inhibition proliferation in human lung adenocarcinoma A549 cells by cytokine-induced killer cells. The difference in genetic relatedness between parents and offspring results into traits such as beauty being more beneficial in a spouse than in an in-law.

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Breakthrough zygomycosis is increasingly observed among patients at high risk for fungal infection who are receiving voriconazole, reflecting either selective pressure or voriconazole-associated alterations in Zygomycetes virulence. These results suggested that subcortical pigment distribution and amino acid uptake in fully grown oocytes were microfilament-dependent processes, whereas protein synthesis in the oocyte was not. Meclofenamic acid and mefenamic acid produced dose-related increases in excitation (to seizure) while ibuprofen, paracetamol and indomethacin produced dose-related increases in sedation. Three-dimensional analysis of thoracic apical sagittal alignment in adolescent idiopathic scoliosis. The French military health service has developed a new auto-injector presenting as a self-usable dual-chamber syringe and successfully obtained a new drug approval to provide this new emergency treatment for the military and civilians.

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Expression of most of the genes disappeared after the third passage, only T-cell marker genes were highly expressed after passages. The half-life of VPA was significantly related to age, but volume of distribution and clearance were not.

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Effect of pH on the binding of N-alkyl sulfates to bovine serum albumin. While the total recombinant virus population is slightly reduced, the total progeny virus is reduced even further, resulting in more than sevenfold enhancement in the frequency of recombinant virus, which allows for more efficient identification. Fluid resuscitation, methylprednisolone and diphenylhydramine were administered intravenously.

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Functional neuroimaging studies demonstrate age-related differences in recruitment of a large-scale attentional network during interference resolution, especially within dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC). No seedlings were found in the field from January 2012 to December 2012, indicating that few seeds were successfully established in the surveyed area.

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Task shifting in surgery: Lessons from an Indian Heart Hospital. A 64 year old woman with partial atrioventricular canal and double orifice mitral valve presented with severe mitral regurgitation secondary to a torn leaflet. This study demonstrated that Fourier analysis provides quantitative measurement of cell motility that may be applied to the study of biological processes.

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Targeted projections, made up of a limited number of coronal source images, showed diverticula and smaller polyps more clearly. American Medical Association and American Osteopathic Association credit systems: accomplishing dual credit for a conference. Compared to related materials such as zeolites, the ability to detect and control defects in MOFs is nascent.

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In the case of both nosocomial and community-acquired infection, previous exhaustive reviews of published and unpublished reports concluded that mortality, likelihood of hospitalization, and length of hospital stay were usually at least twice as great for patients infected with drug-resistant strains as for those infected with drug-susceptible strains of the same bacteria. Americans in Motion-Healthy Interventions (AIM-HI) is an initiative designed to assist family physicians with positioning fitness (physical activity, nutrition, and emotional well-being) as the treatment of choice for prevention and management of chronic disease. Post-partum development of glomerulosclerosis does not seem to be due to augmented apoptosis. Medical literature in PubMed pertaining to similar cases was reviewed.

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The distribution of interstitial collagen types I and III was studied by immunocytochemistry in the mesenchyme of progressing and regressing mesonephric and paramesonephric ducts of male and female rat fetuses from the age of 15 days until birth. Suprascapular nerve entrapment: Diagnosis and results of treatment. In patients with a long life expectancy with high-risk (HR) prostate cancer (PCa), the chance to die from PCa is not negligible and may change significantly according to the time elapsed from surgery.

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Intrauterine infection in humans as well as genital mycoplasmosis in humans and rodents is reviewed. Human transcription factor TFIID contains the TATA-binding protein (TBP) and several TBP-associated factors (TAF(II)s).

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To explore the effect of physical exercise at high altitudes (HA) on male reproductive system. When these agents are used, routine use of an ocular hypotensive agent may be necessary to increase the safety of abandoning the review on the first post-operative day for phacoemulsification patients. In conclusion, these results suggest that podoplanin/CLEC-2 signaling regulates keratinocyte migration via modulating E-cadherin expression through RhoA signaling. When the epithelium is stimulated to proliferate synchronously through a single wave of DNA synthesis and cell division, study of thin sections and freeze-fracture replicas by conventional transmission electron microscopy reveals that gap junctions are formed by the end of the DNA synthetic (S) phase. Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.

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The primate skull physical model data and the critical shear strain associated with the threshold for severe diffuse axonal injury were used to scale data obtained from previous studies to man, and thus derive a diffuse axonal injury tolerance for rotational acceleration for humans. Placement of an uncovered, self-expandable, metal duodenal stent. EUA was performed in seven patients with hepatic cirrhosis (3 cases), lupus nephritis, diabetic nephropathy, and carcinomatous peritonitis (2 cases) for a total of 122 sessions. To determine the feasibility and potential role of combining radiostereometric analysis (RSA), gait analysis and activity monitoring in the follow-up of fracture patients. The lesions appeared after long-term self-medication of high doses.

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There is no study evaluating the influence of morbid obesity and bariatric surgery on antioxidant/oxidant homeostasis of the unstimulated and stimulated human saliva. The effects of alterations of miR-100 expression and its consequences on CRC cell proliferation, apoptosis and migration were demonstrated in cells cultured in vitro. Angiotensin receptor number in the paraventricular nucleus and the subfornical organ, but not in the anterior pituitary gland, was significantly decreased by adrenalectomy, and this effect was reversed by corticoids. In vitro studies demonstrated that all tested isolates were effective in causing nematode mortality compared with the control.

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These studies support a direct relationship between p53 mutations and GLDC expression in B cell lymphoma. Chemical cross linking of two anti TPO-R Microbodies resulted in highly potent TPO mimetics which are promising candidates for the treatment of TPO deficiencies. Identification of Shigella boydii in colonic malacoplakia by universal bacterial 16S ribosomal DNA-based amplification in a human immunodeficiency virus-infected patient. When the previously-kindled, saline groups were crossed to CPP a small depressant effect on seizure expression was observed. Securing adequate vascular access is essential for a successful apheresis procedure.

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Developing countries need rapid, easy-to-operate, simple, and cheap diagnostic tools urgently. Most notably, the Igfbp1 (Insulin-Like Growth Factor Binding Protein 1) was selected as the best candidate gene for early detection of liver damage since it showed early and continuously enhanced induction during the treatment course. Students are exposed to vast amounts of information through technology.

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This study identifies suitable reference genes for relative quantification of gene expression by qPCR after fluoride treatment both in cultured cells and in the rodent enamel organ. Our aim was to monitor the serum levels of IGF-I, IGF-binding protein (IGFBP) 3, and IGFBP-2 during long-term GH treatment of 156 patients with GH deficiency (GHD) and of 153 non-GHD patients. However, the underlying mechanisms for the formation of SDA are not completely understood.

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Identification of mitochondrial genome concatemers in AIDS-associated lymphomas and lymphoid cell lines. Oculo-auriculo-vertebral spectrum with craniosynostosis and osteo-cartilagineous multiple defects: a diffuse chondro-membranous-osteo-dysplasia.

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Characteristics discussed include autonomy, evolvability, robotic outposts, and an overview of future missions. (holotype male and paratype female) from Phu Tho province, northern Vietnam, is described and illustrated. To investigate changes in glycosaminoglycan (GAG) profiles in human prostatic tissue.

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Our studies support using the combination of immunological and proteomic approaches to identify proteins that elicit antigen-specific antibody and Th1-type cytokine responses. Nutrient content in macrophyta collected from southern Baltic Sea beaches in relation to eutrophication and biogas production.

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Nosocomial Clostridium difficile diarrhea--adverse effect of antibiotic therapy This article reviews the use of intraoperative echocardiography during repair of congenital heart defects. We report the isolation of a cDNA that encodes the complete human androgen receptor.

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Syn-cardiolipin exerted protection against cytochrome c-induced caspase-3 activation in a cell-free system, particularly in the presence of H(2)O(2). In either scenario, the use of wastewater effluent as a cultivation medium seems necessary to reduce greenhouse gas emissions and maximize water use efficiency.

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Moreover, in first trimester decidual cells, thrombin enhanced sFlt-1 mRNA levels, as measured by quantitative reverse transcriptase-polymerase chain reaction, and levels of secreted sFlt-1 protein, as measured by enzyme-linked immunosorbent assay. A prospective questionnaire-based survey collected comprehensive informations on the main clinical characteristics of 1484 psoriatic patients. It is concluded that in the majority of patients clouding confined to a few ethmoid cells shown on CT is without clinical significance.

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a general practitioner was 16 days of temporary inability to work in cases of gastric ulcer, and 73 days in cases of duodenal ulcer. The overall incidence of adverse events is similar to that of placebo. In contrast, its three analogs, namely 20b, (R)-31b, and (S)-22b, exert a dose and use-dependent sodium channel block. Our study successfully demonstrated the potential role of phenolics in plant nitrogen acquisition throughout natural environments. Clustering of stromal genes in six cancer data sets resulted in metagenes, each containing three genes, representing matrix production and vascularization.

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The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing. In plants exposed to 30-60 nm Al2O3 NPs, the length of the root including hypocotyl was increased, and proteins related to glycolysis were suppressed.