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Topirol (Topiramate)
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Topiramate

Topirol is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Topirol antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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LH secretory patterns in intact and gonadectomized male and female rats. Post-treatment scans were binned into intervals of 3, 6, 12, 18, 24, 30, and 36 months after the completion of treatment. Attractiveness and its effect on medical students rank order for seeing patients. Educators in action: control of quality with respect to educational programming in hospitals. This study examines whether alpha-tocopherol modulates glomerulosclerosis and tubulointerstitial injury when it is given 2 wk after renal damage has been established.

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Inhibition of hypoxic pulmonary vasoconstriction by increased left atrial pressure in dogs. This study explores the dynamic relationship between participation in social activities and trajectories of depressive symptomatology among older Taiwanese adults surveyed over 18 years.

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Pulmonary edema and hemorrhage (PEH) was induced in rats by cerebral compression and intraveneous norepinephrine. A new interpretation of paranoia according to Elias Canetti, Nobel Prize for Literature 1981 Frequency-domain multiscale quantum mechanics/electromagnetics simulation method. By providing visualizations of static and dynamic network properties simultaneously, it is possible to directly observe the effects of changes in the network structure on the behavior.

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Alternatively, as a single molecule often contains multiple PDZ domains that can interact with each other, it may cluster all these synaptic molecules and facilitate their signaling at synaptic sites. TRIM proteins contain a tripartite domain structure in proximity to their N termini that consists of a RING finger domain, followed by one or two B box domains and a C-terminal coiled-coil domain (collectively termed the RBCC domain). Until the end of the half of pregnancy, biparietal measurement allows for better assessment of gestational age than the date of the last menstrual period. There was no statistically significant correlation between the expression of MRD markers in the PB and BM samples. Theory and experiment on the 1/f gamma noise in p-channel metal-oxide-semiconductor field-effect transistors at low drain bias.

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To determine the prevalence of infections in Brazilian intensive care units and the associated mortality by analyzing the data obtained in the Extended Prevalence of Infection in Intensive Care (EPIC II) study. The mutant selection window hypothesis postulates that, for each antimicrobial-pathogen combination, an antimicrobial concentration range exists in which selective amplification of single-step, drug-resistant mutants occurs. This phenomenon was not associated with symptoms of thrombosis and the patient delivered by caesarean section with no complications. The normative values and distribution parameters for fetal NT, maternal serum free beta-hCG and PAPP-A were established in Saudi singleton pregnancies, the maternal body weight together with smoking, twin pregnancy and ethnicity being important first-trimester screening co-variables.

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From these studies, it is known that a large number of descriptors are strongly correlated and capture similar characteristics of molecules. In both settings, participation in the study declined by 8-month follow-up.

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The parallels between the two systems suggest that a limited set of algorithms for estimating motion satisfies both the needs of sighted creatures and the constraints imposed on them by metabolism, anatomy, and the structure and regularities of the visual world. Two cases of ischemic incidents at the extremities caused by a chronic intoxication with ergotamine tartrate, after its prolonged administration in therapeutical doses as a treatment for hemicrany, are reported.

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This paper describes a framework for effective modeling in RBA risk assessment that is based on four fundamental building blocks: (1) relate severity of drug product change and API properties to reliability of modeling, (2) use critical model variables to express the critical differences in the drug products, (3) generate a fraction-absorbed response surface expressed in terms of the critical model variables to evaluate the relative performance of the drug products, and (4) tie the first three building blocks together by following good model building practices that assure the highest quality model is built. Seven out of 10 patients showed a clinical improvement of the treated psoriatic lesions.

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Anti-discriminatory, woman-centered and intersectional accounts are critiqued for reliance upon both reification and isolation of gender. Importantly, we highlight a catalytic role of atoms inside of the nearest-neighbor heterogeneity shell in providing a mechanism for diffusion and proving the existence of an additional thermodynamic boundary in the supercritical carbon dioxide on an intermediate length scale. Low-Carbohydrate Diet Impairs the Effect of Glucagon in the Treatment of Insulin-Induced Mild Hypoglycemia: A Randomized Crossover Study. Amputation neuroma of common bile duct with obstructive jaundice.

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When compared to other species, many genes previously implicated in male sex determination and differentiation pathways showed conservation in their gonadal expression patterns in bluehead wrasses. Using lentiviral vectors, we established two stable prostate cancer cell lines with altered QKI-5 expression, including a QKI-5 overexpressing PC3 cell line and a DU145 cell line with knocked-down QKI-5 expression. Stochastic dynamics of large-scale inflation in de Sitter space.

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Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 Ras-GTPase-activating protein. Implications for emissions estimation using the different methods are also discussed. Separate activation of the cytoplasmic and nuclear calcium pools in maturing starfish oocytes. A dose-response curve for loss of consciousness after administration of propofol was obtained using 56 unselected, premedicated patients presenting for surgery.

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Regulation of epithelial-mesenchymal transition by tumor-associated macrophages in cancer. In this study, we investigated the mechanical response of the brain to a technique that creates a focal injury in the rat brain. Elevated concentrations of urea after HBO are thought adaptive, serving for elimination of ammonia overproduction in hyperoxia.

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Value of the biological study of cultured cells from benign pigmented nevi. The calibration is immune to the intensity fluctuation of the light source and independent of the circuit parameters. Planning, implementation, and evaluation of a first interprofessional module, Professional Ethics: Issues of Autonomy, was carried out by the interprofessional Working Group with representation from all programs in the faculty. The common finding that the higher accumulation of calcium occurred in the arteries of the lower limbs in comparison to the arteries of the upper limbs and extremely high accumulation of calcium occurred in the common, external, and internal iliac arteries was obtained in the two subjects. The treatment time and chemical structure of the polymers were found to be important factors.

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Then targets of miRNAs were predicted according to information in relevant databases. The 127 patients concerned comprised 94 specific and 33 nonspecific cases. The large genomes of salamanders lead to large cell sizes that necessitate developmental modification and morphological simplification.

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There is only one other case of cryptococcal osteomyelitis reported in the English medical literature in a child. Monitoring of the hearing condition of the infants at risk should be strengthened. The present study reports the case of a maxillary sinus adenocarcinoma that was misdiagnosed as a frog sparganum infection, and discusses the differential diagnosis between the two diseases. In this review, the authors describe the susceptibility genes related to uveitis and AMD and the important advances in pharmacogenetic research in relation to AMD and uveitis therapy.

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In a meeting of German medical oncology experts, the available clinical evidence and own clinical experience regarding the management of patients with advanced pancreatic cancer and hyperbilirubinaemia was discussed. Klippel-Trenaunay-Weber syndrome is a rare cutaneous vascular disorder characterized by the presence of multiple hemangiomata, arteriovenous fistulas, and limb hypertrophy. Minimally invasive abdominal surgery means minimal trauma to the abdominal wall, thus reducing postoperative pain and wound complications, and facilitating earlier mobilization and shorter hospitalization in comparison with conventional surgery. For both studies, a wet electrode radiofrequency (RF) probe was used to deliver 40 W of energy for 18 to 62 seconds after a 30-second infusion of hypertonic saline/Hypaque through the RF antenna. This causes film elements to flow and generates the thickness differences between the absorbed and emerging film elements.

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Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants. The calibrated Heller myotomy was extended for at least 2.5 cm on the esophagus and for 3 cm on the gastric side. The strength of PET in mediastinal staging (its high negative predictive value) was confirmed in a randomized study, in which PET reduced the number of invasive procedures without loss of accuracy in staging.

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We examined whether changes in cytokine production and profile precede other immunological changes and whether these might occur in temporal association with plasma HIV RNA changes. The initial oxidation reaction of ethylene carbonate and dimethyl carbonate at the surface of the completely de-lithiated LiNi0.5Mn1.5O4 high voltage spinel cathode was examined using DFT. Malleus, incus, and stapes were collected from cadaveric temporal bones.

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The data retrieval from such sources is not trivial, due to their redundancy and heterogeneity, and the presence of false evidence. Future interventions should improve the oral health knowledge of dentists and other healthcare professionals regarding the importance of comprehensive dental care, including periodontal treatment when needed, for all pregnant patients. Immunogenetic analysis of pathomorphological forms and prognosis of chronic glomerulonephritis Suppressing IL-6 inhibited in vivo tumour growth and metastasis.

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We were able to automatically distinguish individual zooidal cavities and acquire corresponding morphological datasets. Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study. This exploratory study demonstrates an approach to developing a theoretical understanding of implementation difficulties.

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A regional study of 4-aminobutyrate metabolism and amino acid levels in rat brain following chronic oral administration of ethanolamine O-sulphate. The evoked action potential was also recorded from the cuff electrodes by nerve stimulation via the sieve electrode.

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Histological study of the affected areas showed infiltration of the mucosa by eosinophils, increased mucosal IgE plasma cells, and activated intraepithelial lymphocytes. We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes. It is the consequence of the cooperative interaction among the photocycling bacteriorhodopsin molecules that regulates the yields of more than one (expectedly two main) parallel pathways existing in the millisecond time domain of the photocycle. Holland describes the building of a data base which can be updated and used to plan for manpower needs. The relationship between obesity and total stroke depends on the distribution of stroke subtypes in the population.

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Dosing strategies and optimization of targeted therapy in advanced renal cell carcinoma. A case of gonococcal ophthalmia neonatorum in a preterm boy (gestational age 29 weeks) delivered by caesarean section 22 hours after rupture of the membranes costco prevacid lansoprazole 15 is described. Any impact of blips and low-level viraemia episodes among HIV-infected patients with sustained virological suppression on ART? Moreover, ERM decreased serum creatinine and BUN levels and increased creatinine clearance, and up-regulated expression of mOCT1/2 and mOCTN1/2, contributing to kidney function improvement in this model.

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Splenectomy Correlates With Increased Risk of Pyogenic Liver Abscess: A Nationwide Cohort Study in Taiwan. parahaemolyticus isolates obtained from these outbreaks and showed that this species omeprazole twice daily dosing for levofloxacin consists of a highly diverse population.

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Knockdown of Bcl-xL or cIAP1 with specific small interfering RNAs abolished the CTGF-mediated resistance to apoptosis induced by the chemotherapeutic agents in MCF7/CTGF cells. It was not statistically significant in women, probably because of confounding hormonal influences on excitability. Physiologic instability and increased quantity of care were not associated with chronic protein-energy malnutrition, fat store depletion, or somatic protein store depletion. Based on the mean and standard deviation parameters, we incorporate a Gaussian weighted function into the perspective allopurinol oral tablet 100 mg projection and display the calcification exclusively. It is widely accepted that pannexin 1 (Panx1) channels are responsible for ATP release in diverse cell types, including taste cells.

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